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Metallobio

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MetalloBio is an antimicrobials company, designing and testing completely new types of antibiotic drugs.

123%
 - 
Funded 19 Dec 2024
£570,003 target
£705,232 from 544 investors
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Business overview

Location Sheffield, United Kingdom
Social media
Website www.metallobio.com
Sectors Healthcare Non-Digital B2B
Company number 13295116
Incorporation date 26 Mar 2021
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Investment summary

Type Equity
Valuation (pre-money) £3.3M
Equity offered 17.39%
Share price £3.48
Tax relief

EIS

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Business highlights

  • Established in 26 March 2021 with £300k award
  • First new broad-acting antibiotics in 40 years
  • Data indicate potentially new modes of action
  • Business supported by strong intellectual property
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Key features

  • Secondary Market
  • Nominee investment min. £20.88 +
  • Pitch
  • Key Information
  • Team
  • Updates
  • Investors 544
  • Discussion
  • Documents

Pitch

About the Campaign

Antibiotics fail when bacterial pathogens develop antimicrobial resistance (AMR). All antibiotics in current medical use are affected by AMR. These antibiotics fall into 7 or 8 superfamilies of drugs. MetalloBio is working on the first completely new broad-spectrum antibiotic families in ~40 years.

Market Opportunity

Our antibiotic compounds are well-suited for complicated* infections (*more than 1 pathogen present) including: urinary tract infections, hospital-acquired pneumonia and ventilator-associated pneumonia. Global Pneumonia Therapeutics Market size was valued at USD 9.5 Billion in 2022 and is poised to grow from USD 10.36 Billion in 2023 to USD 20.63 Billion by 2031, at a CAGR of 9% during the forecast period (2024-2031)(Source: Pneumonia Therapeutics Market Size, by Skyquest, February 2024).

Traction & Key Accomplishments

We have received 5 prestigious governmental Innovate UK grants to date. First CEO, Dr Kirsty Smitten, was awarded Forbes 30 Under 30 and Federation of Small Businesses (FSB) Young Entrepreneur of the Year (2023); MetalloBio awarded Small Business of the Year (2023). We have established 2 business tracks (antibiotic licensing; access to coatings technology (collaborations with 2 industry partners); developed drug formulation; scaled up drug synthesis; and built an intellectual property portfolio.

Use of Funds

Testing compounds against multiple bacterial species:
Target: £570,000: antibiotic potency and mechanisms of killing; impact on all growth stages, including dormancy; duration of antibiotic action.

Stretch raise: £750,000: combinations of antibiotics with our most promising drug candidates.

*Please note, that this is an early stage company that is still in development, and will rely on investment generated to scale and become commercially active. Please ensure you are comfortable with the risks associated and are prepared to lose all of the money you invest.

Our late founder, Dr Kirsty Smitten, who discovered this breakthrough and left an inspirational mission for the MetalloBio team.


The campaign video has been approved by Prosper on 05/11/2024.

Video sources:

1. World Health Organisation (WHO): Global antimicrobial resistance forum launched to help tackle common threat to planetary health, published April 2023

2. World Health Organisation (WHO): Antibiotic Resistance, published 21 November 2023.

3. “Bad Bugs, No Drugs 2002-2020: Progress, Challenges, and Call to Action” by Helen W Boucher
Transactions of the American Clinical and Climatological Association (2020) 131, 65-71.

4. “Novel classes of antibiotics or more of the same?” by Anthony R.M. Coates, Gerry Halls, Yanmin Hu British Journal of Pharmacology (2011) 163, 184-194.

5. “Media representation of the antimicrobial resistance (AMR) crisis: An Australian Perspective” by S.L. Bouchoucha, E. Whatman, M. -J. Johnstone. Infection, Disease & Health (2019) 24, 23-31.

6. World Health Organisation (WHO): Antibiotic Resistance, published 21 November 2023.

7. World Health Organisation (WHO): Global Action Plan on Antimicrobial Resistance, published 1 January 2016.

8. ‘Catheter-Associated Urinary Tract Injections: Current Challenges and Future Prospects’ by Glenn T Werneburg. Research and Reports in Urology (2022) 14, 109-133.

9. ‘Point of care testing for bacterial infection/antibiotic sensitivities’ published 14 April 2022 by NHS Health Research Authority.

10. ‘Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050’ by the GDB 2021 Antimicrobial Resistance Collaborators, Contact Author Christopher J.L. Murray - Lancet (2024) 404, 1199-1226

11. ‘Antibiotic resistance industry is projected to witness a CAGR of 5.3% during the period 2023-2032. This growth can be attributed to the increasing global publish health concern and awareness’ published 31 October 2023 by Global Market Insights Inc.

12. ‘Antimicrobial Coatings Market by Type (Silver, Copper, Titanium Dioxide), Application (Medical & Healthcare, Food & Beverage, Building & Construction, HVAC System, Protective Clothing, Transportation), & Region – Global Forecast To 2025’ reported by MarketsandMarkets.

13. ‘Antimicrobial Additives Market Size, Share & Trends Analysis Report By Type (Organic Inorganic), By Application (Plastics, Paints & Coatings, Pulp & Paper), By End-User, By Region, And Segment Forecasts, 2024-2030’ by Grand View Research.

Key Information

IP Agreement

The company has entered into an exclusive IP licence agreement with the University of Sheffield relating to novel ruthenium-based compounds, including the Patents, the Know-how and the Data.

MetalloBio shares 10% of all sublicense income after it has received a cumulative total of £1,750,000 Sub-Licensing Income and is due to pay royalties of 1.5%, 3% or 4% of the Net Sales Value of all Licensed Therapeutic and Non-Therapeutic Products depending on patent status at the time of sales. The company also must pay a series of one-off payments Development Milestone Payments:

• £85,000 on Recruitment of the first patient to the first “first in man” (Phase I) trial for the first Licensed Therapeutic Product

• £150,000 on the recruitment of the first patient to the first randomised Phase II trial for the first Licensed Therapeutic Product

• £500,000 per event on the recruitment of the first patient to a Phase III trial for each Licensed Therapeutic Product and each indication thereof.

• £500,000 per event on grant of marketing approval for each Licensed Therapeutic Product and each indication thereof in each of the major markets

• £500,000 per event on the first sale of each Licensed Therapeutic Product and each indication thereof in each of the major markets.

The University of Sheffield may terminate the Agreement if the company or any sub-licensee materially breach the conditions of the Agreement. The university also has the termination right if an independent expert determines that the company has failed to comply with its obligations of using diligent efforts to develop, commercialise and maximise sales of the Licensed Products.

The IP can be assigned to MetalloBio once the company secures cumulatively £5 million in dilutive and non-dilutive funding and commercial income. At this event, MetalloBio is due to repay a one-off fee of £56.4k which relates to historical patenting costs borne by the University before the IP Licence Agreement.

Outstanding Convertibles

The company has the following outstanding convertible loans, which may convert to equity after this round and dilute existing shareholders:

1 - £40,713.00 loan from The University of Sheffield, with the following key terms:
• Interest rate: 6%
• Conversion trigger: Fundraising in aggregate in excess of £1,000,000, upon written request from the company,
• Conversion price: the lowest price per share paid by investors for the most senior class of shares issued in a Fundraising less a discount of 20%,
• Valuation Cap: N/A
• Share class: Ordinary or the most senior share class if this carry greater rights
• Repayment date: July 2026

2 - £74,129.00 loan from The University of Sheffield, with the following key terms:
•Interest rate: 6%
• Conversion trigger: Fundraising in aggregate in excess of £1,000,000, upon written request from the company,
• Conversion price: the lowest price per share paid by investors for the most senior class of shares issued in a Fundraising less a discount of 20%,
• Valuation Cap: N/A
• Share class: Ordinary or the most senior share class if this carry greater rights
• Repayment date: Under negotiation.

3 - £137,702.00 loan from The University of Sheffield, with the following key terms:
• Interest rate: 6%
• Conversion trigger: Fundraising in aggregate in excess of £1,000,000, upon written request from the company,
• Conversion price: the lowest price per share paid by investors for the most senior class of shares issued in a Fundraising less a discount of 20%,
• Valuation Cap: N/A
• Share class: Ordinary or the most senior share class if this carry greater rights
•Repayment date: May 2025

Share classes

The company currently has 4 classes of shares: Ordinary, A Ordinary and B Ordinary and Deferred Shares. All investors in this round, including Republic Europe investors, will receive A Ordinary shares.

The rights attached to the share classes are as follows:

1 - Ordinary shares:
• Full dividend rights
• Voting rights
• In the event that the Sale Proceeds divided by the number of Equity Shares is the same or less than £3.477 per Equity Share: 0.1% of the Sale Proceeds to the Ordinary Shareholders pro rata to their respective holdings. Once the Ordinary A Shareholders have received their Priority Amount, any remainder of the Sale Proceeds will be distributed to the Ordinary Shareholders and the Ordinary B Shareholders on a pro rata basis.
• In the event that the Sale Proceeds divided by the number of Equity Shares exceeds £3.477 per Equity Share: pro rata

2 - A ordinary shares:
• Full dividend rights
• Voting rights
• In the event that the Sale Proceeds divided by the number of Equity Shares is the same or less than £3.477 per Equity Share: the Ordinary A Shareholders 99.9% of the Sale Proceeds pro rata to their respective holdings.
• In the event that the Sale Proceeds divided by the number of Equity Shares exceeds £3.477 per Equity Share: pro rata

3 - B ordinary shares
• Full dividend rights
• No voting rights
• On a winding-up event, receive one penny in aggregate for the entire class.
• In the event that the Sale Proceeds divided by the number of Equity Shares is the same or less than £3.477 per Equity Share: once the Ordinary A Shareholders have received their Priority Amount, any remainder of the Sale Proceeds will be distributed to the Ordinary Shareholders and the Ordinary B Shareholders on a pro rata basis.
• In the event that the Sale Proceeds divided by the number of Equity Shares exceeds £3.477 per Equity Share: pro rata capped at £1,095,255, which is the total B shares value at the current round share price (£3.477).

4 - Deferred shares
• No dividend rights
• No voting rights;
• On a winding up or Share Sale event, receive one penny in aggregate for the entire class.

Direct investments

The direct investments reflected in this campaign as part of this round were received by the Company in April 2024 and the Company has started putting this to use according to the use of proceeds section. The direct investors paid a slightly lower share price (£3.477) due to the need of rounding the share price to two decimal places on the platform.

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If you successfully purchase a share lot of this business, you will be granted access.

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Only shareholders can access this page

If you successfully purchase a share lot of this business, you will be granted access.

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Investing involves risks, including loss of capital, illiquidity, lack of dividends and dilution, and should be done only as part of a diversified portfolio. Please read the Risk Warnings before investing. Investments should only be made by investors who understand these risks. Tax treatment depends on individual circumstances and is subject to change in future.

This webpage is issued by Seedrs Limited (trading as Republic Europe) ("Republic Europe"), and has been approved as a financial promotion for the purposes of s.21 of the Financial Services and Markets Act 2000 by Prosper Capital LLP ("Prosper") which is authorised and regulated by the Financial Conduct Authority with firm reference number 453007 on 18 October 2024. It is not intended to be a promotion of any individual investment opportunity and is not an offer to the public. The summary information provided about investment opportunities on this webpage is intended solely to demonstrate the types of investments available on the Republic Europe platform, and any investment decision should be made on the basis of the full campaign. Full campaigns are available to investors who have become authorised to invest on the Republic Europe platform. It is not for distribution in the United States of America and all investment activities take place within the United Kingdom. Any person resident outside the United Kingdom should ensure that they are not subject to any local regulations before investing.

Neither Republic Europe nor Prosper provide advice or recommendations in relation to any investment on this site. No communications from Republic Europe, through this website or any other medium, should be construed as an investment recommendation. Further, nothing on this website shall be considered an offer to sell, or a solicitation of an offer to buy, any security to any person in any jurisdiction to whom or in which such offer, solicitation or sale is unlawful. Neither Republic Europe nor Prosper provides legal, financial or tax advice of any kind. If you have any questions with respect to legal, financial or tax matters relevant to your interactions with Republic Europe, you should consult a professional adviser.

Tax Relief (SEIS)

This business is eligible for SEIS relief - providing qualifying investors with income tax relief of 50% of their investment and certain other tax reliefs. Tax treatment depends on individual circumstances and is subject to change in future. Click to learn more.

Tax Relief (EIS)

This business is eligible for EIS relief - providing qualifying investors with income tax relief of 30% of their investment and certain other tax reliefs. Tax treatment depends on individual circumstances and is subject to change in future. Click to learn more.

Valuation (pre-money)

Valuation rounded from £3,348,143

This is the fully-diluted pre-money valuation of the business (i.e. before the new investment comes in and including issued options and other equity interests). In contrast, the post-money valuation is based on inclusion of the new investment in the value.

It is calculated as the pre-money valuation plus the amount of new investment. e.g. If Company A is ascribed a pre-money valuation of £1,200,000 by prospective investors investing £300,000, its post-money valuation is £1,500,000.

The investee business is responsible for setting its own valuation, it has not been prescribed by Seedrs.

Pitch type

Investing in a regular equity campaign is the simplest and most common way to invest in a startup. You decide which business you want to invest in, and if the campaign hits its funding target then you will become one of their shareholders. As the company becomes more valuable, so do your shares; allowing you the opportunity to share in the future success of the business.

Learn more about pitch type on Seedrs

Equity Offered

The equity offered is the percentage of the company’s shares being issued in return for the amount of investment raised.

When the amount raised is less than 100%, the equity offered is based on the target raise. Once the company has raised over 100% it is based on the total raised.

In some scenarios, entrepreneurs may accept additional direct investment after closing their Seedrs campaign. Provided this is within 6 months of the closing and on the same terms, we do not typically offer pre-emption rights on that extra investment (where you have the opportunity to invest again to maintain your percentage shareholding).

Learn more about investing and pre-emption rights.

Nominee investment

This shows if you are able to choose, when making an investment, that you be represented by, and your shareholding be managed by, the Nominee investment.

Find out more

Custodian

If you invest in this Campaign, Seedrs will act as Custodian rather than provide our standard nominee service. This is due to the fact that the business is not directly involved in the share sale and Seedrs will not benefit from any rights under a shareholder agreement. As a result, Seedrs will handle administrative tasks as we do normally, but you will not have information or voting rights, updates from the business, preemption on future fundraising, or ongoing support about business trading activity.

Learn more about Custodian here

Secondary market

This shows if the business has opted-in or opted-out of allowing its shares to be bought and sold on the secondary market.

Find out more

Direct investment

This is an option to invest and hold shares 'directly' in the company (rather than via the Nominee investment). This option is only available to those investing over the threshold amount, which is determined by the fundraising company.

If you choose to hold your shares directly, you will be responsible for any contractual or administrative arrangements with the company you are investing in.

Find out more

Payment options

We are not able to accept card payments for investments into this sector. You can pay for your investment by creating a bank transfer, using funds in your investment account or create a Pay by Bank payment. Your investment will only be completed once the funds have reached our account.

Business Involvement

This Campaign offers shares for sale in business that is not directly involved in this Campaign or the sale. As a result, the Campaign and post-investment experience, including investor rights, will differ from a business-led campaign on Seedrs. Most notably, the business will not engage with investors in the discussion forums both during and after the sale or provide any updates to investors.

Learn more here

Payment options

We are not able to accept Pay by Bank payments for investments into this sector. You can pay for your investment with a card payment, by creating a bank transfer or by using funds in your investment account. Your investment will only be completed once the funds have reached our account.

Drawdowns

This campaign offers the ability to pay for an investment by drawdowns.

Security Token

A security token is a digital asset that represents ownership or other rights. It is a digital form of traditional investments. In the future, you may be able to trade your investment through compatible exchanges.

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